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TitlePhosphorylation of Neuronal Lysine-Specific Demethylase 1Lsd1/Kdm1A Impairs Transcriptional Repression by Regulating Interaction with Corest and Histone Deacetylases Hdac1/2.
Journal, issue, pagesJ. Neurochem., Vol. 128, Page 616-, Year 2014
Publish dateSep 17, 2012 (structure data deposition date)
AuthorsToffolo, E. / Rusconi, F. / Paganini, L. / Tortorici, M. / Pilotto, S. / Heise, C. / Verpelli, C. / Tedeschi, G. / Maffioli, E. / Sala, C. ...Toffolo, E. / Rusconi, F. / Paganini, L. / Tortorici, M. / Pilotto, S. / Heise, C. / Verpelli, C. / Tedeschi, G. / Maffioli, E. / Sala, C. / Mattevi, A. / Battaglioli, E.
External linksJ. Neurochem. / PubMed:24111946
MethodsX-ray diffraction
Resolution3.1 Å
Structure data

PDB-4bay:
Phosphomimetic mutant of LSD1-8a splicing variant in complex with CoREST
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-FAD:
FLAVIN-ADENINE DINUCLEOTIDE / FAD*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / DEMETHYLASE SPLICING CHROMATIN

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