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Structure paper

TitleIdentification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 110, Page 17456-17461, Year 2013
Publish dateAug 31, 2012 (structure data deposition date)
AuthorsDonaldson, J.M. / Zer, C. / Avery, K.N. / Bzymek, K.P. / Horne, D.A. / Williams, J.C.
External linksProc. Natl. Acad. Sci. USA / PubMed:24101516
MethodsX-ray diffraction
Resolution1.95 - 2.24 Å
Structure data

PDB-4gw1:
cQFD Meditope
Method: X-RAY DIFFRACTION / Resolution: 2.24 Å

PDB-4gw5:
cQYN meditope - Cetuximab Fab
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-4hjg:
Meditope-enabled trastuzumab
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-4hkz:
Trastuzumab Fab complexed with Protein L and Protein A fragments
Method: X-RAY DIFFRACTION / Resolution: 2.08 Å

PDB-4ioi:
Meditope-enabled trastuzumab in complex with CQFDLSTRRLKC
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
  • staphylococcus aureus (bacteria)
  • finegoldia magna (bacteria)
KeywordsIMMUNE SYSTEM / IgG / EGFR / monoclonal antibody / cancer therapeutic / cancer immunotherapy

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