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TitleInsights into soluble guanylyl cyclase activation derived from improved heme-mimetics.
Journal, issue, pagesJ. Med. Chem., Vol. 56, Page 8948-8952, Year 2013
Publish dateMar 20, 2013 (structure data deposition date)
Authorsvon Wantoch Rekowski, M. / Kumar, V. / Zhou, Z. / Moschner, J. / Marazioti, A. / Bantzi, M. / Spyroulias, G.A. / van den Akker, F. / Giannis, A. / Papapetropoulos, A.
External linksJ. Med. Chem. / PubMed:24090476
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-4jqh:
Crystal structure of a new sGC activator (analogue of BAY 58-2667) bound to nostoc H-NOX domain
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-1MF:
4-{[(4-carboxybutyl)(2-{2-[(4'-phenoxybiphenyl-4-yl)methoxy]phenyl}ethyl)amino]methyl}benzoic acid

ChemComp-MLA:
MALONIC ACID

ChemComp-HOH:
WATER

Source
  • nostoc sp. (bacteria)
KeywordsSIGNALING PROTEIN / GUANYLYL CYCLASE / analogue of BAY58-2667

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