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Structure paper

TitleStructure of the factor VIII C2 domain in a ternary complex with 2 inhibitor antibodies reveals classical and nonclassical epitopes.
Journal, issue, pagesBlood, Vol. 122, Page 4270-4278, Year 2013
Publish dateMay 1, 2013 (structure data deposition date)
AuthorsWalter, J.D. / Werther, R.A. / Brison, C.M. / Cragerud, R.K. / Healey, J.F. / Meeks, S.L. / Lollar, P. / Spiegel, P.C.
External linksBlood / PubMed:24085769
MethodsX-ray diffraction
Resolution2.47 Å
Structure data

PDB-4ki5:
Cystal structure of human factor VIII C2 domain in a ternary complex with murine inhbitory antibodies 3E6 and G99
Method: X-RAY DIFFRACTION / Resolution: 2.47 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / immunoglobulin fold / discoidin fold / antibody / blood coagulation factor / antigen binding / blood plasma

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