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TitleDivergent evolution of protein conformational dynamics in dihydrofolate reductase.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 20, Page 1243-1249, Year 2013
Publish dateAug 9, 2013 (structure data deposition date)
AuthorsBhabha, G. / Ekiert, D.C. / Jennewein, M. / Zmasek, C.M. / Tuttle, L.M. / Kroon, G. / Dyson, H.J. / Godzik, A. / Wilson, I.A. / Wright, P.E.
External linksNat. Struct. Mol. Biol. / PubMed:24077226
MethodsX-ray diffraction
Resolution1.201 - 1.7 Å
Structure data

PDB-4m6j:
Crystal structure of human dihydrofolate reductase (DHFR) bound to NADPH
Method: X-RAY DIFFRACTION / Resolution: 1.201 Å

PDB-4m6k:
Crystal structure of human dihydrofolate reductase (DHFR) bound to NADP+ and folate
Method: X-RAY DIFFRACTION / Resolution: 1.396 Å

PDB-4m6l:
Crystal structure of human dihydrofolate reductase (DHFR) bound to NADP+ and 5,10-dideazatetrahydrofolic acid
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-HOH:
WATER

ChemComp-FOL:
FOLIC ACID

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-GOL:
GLYCEROL

ChemComp-21V:
N-(4-{2-[(6S)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl]ethyl}benzoyl)-L-glutamic acid

ChemComp-DTT:
2,3-DIHYDROXY-1,4-DITHIOBUTANE

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / Rossmann Fold / NADPH binding / folate binding

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