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-Structure paper
Title | The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design. |
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Journal, issue, pages | Oncotarget, Vol. 4, Page 1647-1661, Year 2013 |
Publish date | Aug 21, 2013 (structure data deposition date) |
Authors | Couty, S. / Westwood, I.M. / Kalusa, A. / Cano, C. / Travers, J. / Boxall, K. / Chow, C.L. / Burns, S. / Schmitt, J. / Pickard, L. ...Couty, S. / Westwood, I.M. / Kalusa, A. / Cano, C. / Travers, J. / Boxall, K. / Chow, C.L. / Burns, S. / Schmitt, J. / Pickard, L. / Barillari, C. / McAndrew, P.C. / Clarke, P.A. / Linardopoulos, S. / Griffin, R.J. / Aherne, G.W. / Raynaud, F.I. / Workman, P. / Jones, K. / van Montfort, R.L. |
External links | Oncotarget / PubMed:24072592 |
Methods | X-ray diffraction |
Resolution | 1.58 - 2.19 Å |
Structure data | PDB-4c33: PDB-4c34: PDB-4c35: PDB-4c36: PDB-4c37: PDB-4c38: |
Chemicals | ChemComp-HOH: ChemComp-STU: ChemComp-GOL: ChemComp-MG8: ChemComp-NU3: ChemComp-MPD: ChemComp-ZO9: ChemComp-MOH: ChemComp-Z21: ChemComp-VUP: |
Source |
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Keywords | TRANSFERASE/INHIBITOR / TRANSFERASE-INHIBITOR COMPLEX / CHIMERA / S6K1 |