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TitleNovel complex crystal structure of prolyl hydroxylase domain-containing protein 2 (PHD2): 2,8-Diazaspiro[4.5]decan-1-ones as potent, orally bioavailable PHD2 inhibitors
Journal, issue, pagesBioorg. Med. Chem., Vol. 21, Page 6349-6358, Year 2013
Publish dateApr 3, 2013 (structure data deposition date)
AuthorsDeng, G. / Zhao, B. / Ma, Y. / Xu, Q. / Wang, H. / Yang, L. / Zhang, Q. / Guo, T.B. / Zhang, W. / Jiao, Y. ...Deng, G. / Zhao, B. / Ma, Y. / Xu, Q. / Wang, H. / Yang, L. / Zhang, Q. / Guo, T.B. / Zhang, W. / Jiao, Y. / Cai, X. / Zhang, J. / Liu, H. / Guan, X. / Lu, H. / Xiang, J. / Elliott, J.D. / Lin, X. / Ren, F.
External linksBioorg. Med. Chem. / PubMed:24055079
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-4jzr:
Structure of Prolyl Hydroxylase Domain-containing Protein (PHD) with Inhibitors
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-NI:
NICKEL (II) ION

ChemComp-4JR:
2-(biphenyl-4-yl)-8-[(1-methyl-1H-imidazol-2-yl)methyl]-2,8-diazaspiro[4.5]decan-1-one

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / Prolyl hydroxylase

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