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TitleDirected Evolution of Mycobacterium Tuberculosis Beta-Lactamase Reveals Gatekeeper Residue that Regulates Antibiotic Resistance and Catalytic Efficiency.
Journal, issue, pagesPlos One, Vol. 8, Page 73123-, Year 2013
Publish dateDec 21, 2012 (structure data deposition date)
AuthorsFeiler, C. / Fisher, A.C. / Boock, J.T. / Marrichi, M.J. / Wright, L. / Schmidpeter, P.A.M. / Blankenfeldt, W. / Pavelka, M. / Delisa, M.P.
External linksPlos One / PubMed:24023821
MethodsX-ray diffraction
Resolution2.85 Å
Structure data

PDB-3zhh:
X-ray structure of the full-length beta-lactamase from M.tuberculosis
Method: X-RAY DIFFRACTION / Resolution: 2.85 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • mycobacterium tuberculosis (bacteria)
KeywordsHYDROLASE

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