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Structure paper

TitleStructure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 20, Page 1221-1223, Year 2013
Publish dateMay 30, 2013 (structure data deposition date)
AuthorsToms, A.V. / Deshpande, A. / McNally, R. / Jeong, Y. / Rogers, J.M. / Kim, C.U. / Gruner, S.M. / Ficarro, S.B. / Marto, J.A. / Sattler, M. ...Toms, A.V. / Deshpande, A. / McNally, R. / Jeong, Y. / Rogers, J.M. / Kim, C.U. / Gruner, S.M. / Ficarro, S.B. / Marto, J.A. / Sattler, M. / Griffin, J.D. / Eck, M.J.
External linksNat. Struct. Mol. Biol. / PubMed:24013208
MethodsX-ray diffraction
Resolution1.8 - 1.9 Å
Structure data

PDB-4l00:
Crystal structure of the apo Jak1 pseudokinase domain
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-4l01:
Crystal structure of the V658F apo Jak1 pseudokinase domain
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / kinase domain fold / regulatory

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