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TitleStructural Mimicry of A-Loop Tyrosine Phosphorylation by a Pathogenic FGF Receptor 3 Mutation.
Journal, issue, pagesStructure, Vol. 21, Page 1889-1896, Year 2013
Publish dateApr 10, 2013 (structure data deposition date)
AuthorsHuang, Z. / Chen, H. / Blais, S. / Neubert, T.A. / Li, X. / Mohammadi, M.
External linksStructure / PubMed:23972473
MethodsX-ray diffraction
Resolution2.3405 Å
Structure data

PDB-4k33:
Crystal Structure of FGF Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, a Gain-of-Function Mutation Responsible for Thanatophoric Dysplasia Type II and Spermatocytic Seminoma
Method: X-RAY DIFFRACTION / Resolution: 2.3405 Å

Chemicals

ChemComp-ACP:
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER / AMP-PCP, energy-carrying molecule analogue*YM

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Kinase Domain Fold Consisting of N- and C-lobes / Receptor Tyrosine Kinase

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