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TitleThe Chemical Basis of Serine Palmitoyltransferase Inhibition by Myriocin.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 135, Page 14276-, Year 2013
Publish dateMay 9, 2013 (structure data deposition date)
AuthorsWadsworth, J.M. / Clarke, D.J. / Mcmahon, S.A. / Lowther, J.P. / Beattie, A.E. / Langridge-Smith, P.R.R. / Broughton, H.B. / Dunn, T.M. / Naismith, J.H. / Campopiano, D.J.
External linksJ. Am. Chem. Soc. / PubMed:23957439
MethodsX-ray diffraction
Resolution1.62 Å
Structure data

PDB-4bmk:
Serine Palmitoyltransferase K265A from S. paucimobilis with bound PLP- Myriocin Aldimine
Method: X-RAY DIFFRACTION / Resolution: 1.62 Å

Chemicals

ChemComp-PLP:
PYRIDOXAL-5'-PHOSPHATE

ChemComp-MYB:
Decarboxylated Myriocin

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • sphingomonas paucimobilis (bacteria)
KeywordsTRANSFERASE/ANTIBIOTIC / TRANSFERASE-ANTIBIOTIC COMPLEX / TRANSFERASE / EXTERNAL ALDIMINE / INHIBITOR / SPHINGOLIPIDS / NATURAL PRODUCT / ANTIBIOTIC ISP-1

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