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TitleStapled alpha-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 110, Page E3445-E3454, Year 2013
Publish dateOct 10, 2013 (structure data deposition date)
AuthorsChang, Y.S. / Graves, B. / Guerlavais, V. / Tovar, C. / Packman, K. / To, K.H. / Olson, K.A. / Kesavan, K. / Gangurde, P. / Mukherjee, A. ...Chang, Y.S. / Graves, B. / Guerlavais, V. / Tovar, C. / Packman, K. / To, K.H. / Olson, K.A. / Kesavan, K. / Gangurde, P. / Mukherjee, A. / Baker, T. / Darlak, K. / Elkin, C. / Filipovic, Z. / Qureshi, F.Z. / Cai, H. / Berry, P. / Feyfant, E. / Shi, X.E. / Horstick, J. / Annis, D.A. / Manning, A.M. / Fotouhi, N. / Nash, H. / Vassilev, L.T. / Sawyer, T.K.
External linksProc. Natl. Acad. Sci. USA / PubMed:23946421
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-4n5t:
The 1.7A Crystal Structure of MDMX with a Stapled Peptide, ATSP-7041
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • danio rerio (zebrafish)
  • synthetic construct (others)
KeywordsCELL CYCLE/CELL CYCLE INHIBITOR / MDM4 / p53 / apoptosis / cell cycle / p53 antagonist / nucleus / CELL CYCLE-CELL CYCLE INHIBITOR complex

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