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TitleStructure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR).
Journal, issue, pagesJ. Med. Chem., Vol. 56, Page 7025-7048, Year 2013
Publish dateJul 2, 2013 (structure data deposition date)
AuthorsWard, R.A. / Anderton, M.J. / Ashton, S. / Bethel, P.A. / Box, M. / Butterworth, S. / Colclough, N. / Chorley, C.G. / Chuaqui, C. / Cross, D.A. ...Ward, R.A. / Anderton, M.J. / Ashton, S. / Bethel, P.A. / Box, M. / Butterworth, S. / Colclough, N. / Chorley, C.G. / Chuaqui, C. / Cross, D.A. / Dakin, L.A. / Debreczeni, J.E. / Eberlein, C. / Finlay, M.R. / Hill, G.B. / Grist, M. / Klinowska, T.C. / Lane, C. / Martin, S. / Orme, J.P. / Smith, P. / Wang, F. / Waring, M.J.
External linksJ. Med. Chem. / PubMed:23930994
MethodsX-ray diffraction
Resolution2.64 Å
Structure data

PDB-4li5:
EGFR-K IN COMPLEX WITH N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxy-phenyl] Prop-2-enamide
Method: X-RAY DIFFRACTION / Resolution: 2.64 Å

Chemicals

ChemComp-1WY:
N-(3-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-4-methoxyphenyl)propanamide

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / EGF RECEPTOR KINASE / INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR complex

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