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TitleRole of human hypoxanthine Guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir).
Journal, issue, pagesMol. Pharmacol., Vol. 84, Page 615-629, Year 2013
Publish dateMay 8, 2013 (structure data deposition date)
AuthorsNaesens, L. / Guddat, L.W. / Keough, D.T. / van Kuilenburg, A.B. / Meijer, J. / Vande Voorde, J. / Balzarini, J.
External linksMol. Pharmacol. / PubMed:23907213
MethodsX-ray diffraction
Resolution2.728 Å
Structure data

PDB-4kn6:
Crystal structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with 6-fluoro-3-hydroxy-2-pyrazinecarboxamide (T-705) ribose-5'-monophosphate
Method: X-RAY DIFFRACTION / Resolution: 2.728 Å

Chemicals

ChemComp-1RP:
6-fluoro-3-oxo-4-(5-O-phosphono-beta-D-ribofuranosyl)-3,4-dihydropyrazine-2-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Favipiravir / 6-oxopurine phosphoribosyltransferase

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