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TitleIdentification of the molecular attributes required for aminoglycoside activity against Leishmania.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 110, Page 13333-13338, Year 2013
Publish dateApr 10, 2013 (structure data deposition date)
AuthorsShalev, M. / Kondo, J. / Kopelyanskiy, D. / Jaffe, C.L. / Adir, N. / Baasov, T.
External linksProc. Natl. Acad. Sci. USA / PubMed:23898171
MethodsX-ray diffraction
Resolution1.415 - 2.5 Å
Structure data

PDB-4k31:
Crystal structure of apramycin bound to the leishmanial rRNA A-site
Method: X-RAY DIFFRACTION / Resolution: 1.415 Å

PDB-4k32:
Crystal structure of geneticin bound to the leishmanial rRNA A-site
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-AM2:
APRAMYCIN / antibiotic*YM

ChemComp-HOH:
WATER

ChemComp-GET:
GENETICIN / antibiotic*YM

Source
  • leishmania (eukaryote)
KeywordsRNA/antibiotic / rRNA duplex / Ribosomal A-site / Aminoglycoside / Ribosome / RNA / RNA-antibiotic complex / Leishmanial ribosome

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