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-Structure paper
Title | Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 110, Page E2987-E2996, Year 2013 |
Publish date | Apr 10, 2013 (structure data deposition date) |
Authors | Merchant, M. / Ma, X. / Maun, H.R. / Zheng, Z. / Peng, J. / Romero, M. / Huang, A. / Yang, N.Y. / Nishimura, M. / Greve, J. ...Merchant, M. / Ma, X. / Maun, H.R. / Zheng, Z. / Peng, J. / Romero, M. / Huang, A. / Yang, N.Y. / Nishimura, M. / Greve, J. / Santell, L. / Zhang, Y.W. / Su, Y. / Kaufman, D.W. / Billeci, K.L. / Mai, E. / Moffat, B. / Lim, A. / Duenas, E.T. / Phillips, H.S. / Xiang, H. / Young, J.C. / Vande Woude, G.F. / Dennis, M.S. / Reilly, D.E. / Schwall, R.H. / Starovasnik, M.A. / Lazarus, R.A. / Yansura, D.G. |
External links | Proc. Natl. Acad. Sci. USA / PubMed:23882082 |
Methods | X-ray diffraction |
Resolution | 2.8 Å |
Structure data | PDB-4k3j: |
Chemicals | ChemComp-NAG: ChemComp-HOH: |
Source |
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Keywords | Transferase/Immune System/Growth Factor / antibody / glycosylation / Transferase-Immune System-Growth Factor complex |