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Structure paper

TitleStructure of class B GPCR corticotropin-releasing factor receptor 1.
Journal, issue, pagesNature, Vol. 499, Page 438-443, Year 2013
Publish dateApr 15, 2013 (structure data deposition date)
AuthorsHollenstein, K. / Kean, J. / Bortolato, A. / Cheng, R.K. / Dore, A.S. / Jazayeri, A. / Cooke, R.M. / Weir, M. / Marshall, F.H.
External linksNature / PubMed:23863939
MethodsX-ray diffraction
Resolution2.977 Å
Structure data

PDB-4k5y:
Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395
Method: X-RAY DIFFRACTION / Resolution: 2.977 Å

Chemicals

ChemComp-1Q5:
3,6-dimethyl-N-(pentan-3-yl)-2-(2,4,6-trimethylphenoxy)pyridin-4-amine

ChemComp-OLA:
OLEIC ACID

ChemComp-OLC:
(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate

ChemComp-SO4:
SULFATE ION

ChemComp-PGW:
(1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl / phospholipid*YM

ChemComp-1PE:
PENTAETHYLENE GLYCOL / precipitant*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • enterobacteria phage t4 (virus)
KeywordsMEMBRANE PROTEIN / RECEPTOR / 7TM / GPCR / FAMILY B / SIGNALLING PROTEIN / G-PROTEIN / MEMBRANE

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