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TitleHeavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites.
Journal, issue, pagesJ. Virol., Vol. 87, Page 10173-10181, Year 2013
Publish dateJun 20, 2013 (structure data deposition date)
AuthorsAcharya, P. / Luongo, T.S. / Georgiev, I.S. / Matz, J. / Schmidt, S.D. / Louder, M.K. / Kessler, P. / Yang, Y. / McKee, K. / O'Dell, S. ...Acharya, P. / Luongo, T.S. / Georgiev, I.S. / Matz, J. / Schmidt, S.D. / Louder, M.K. / Kessler, P. / Yang, Y. / McKee, K. / O'Dell, S. / Chen, L. / Baty, D. / Chames, P. / Martin, L. / Mascola, J.R. / Kwong, P.D.
External linksJ. Virol. / PubMed:23843638
MethodsX-ray diffraction
Resolution2.14 Å
Structure data

PDB-4laj:
Crystal structure of HIV-1 YU2 envelope gp120 glycoprotein in complex with CD4-mimetic miniprotein, M48U1, and llama single-domain, broadly neutralizing, co-receptor binding site antibody, JM4
Method: X-RAY DIFFRACTION / Resolution: 2.14 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-ACA:
6-AMINOHEXANOIC ACID / inhibitor*YM

ChemComp-HOH:
WATER

Source
  • human immunodeficiency virus 1
  • lama glama (llama)
KeywordsVIRAL PROTEIN/INHIBITOR / CD4-induced antibody / HIV-1 neutralizing antibody / HIV-1 gp120 reactive / VIRAL PROTEIN-INHIBITOR complex

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