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TitleStructure of conjugated polyketone reductase from Candida parapsilosis IFO 0708 reveals conformational changes for substrate recognition upon NADPH binding
Journal, issue, pagesAppl. Microbiol. Biotechnol., Vol. 98, Page 243-249, Year 2014
Publish dateSep 13, 2012 (structure data deposition date)
AuthorsQin, H.-M. / Yamamura, A. / Miyakawa, T. / Kataoka, M. / Nagai, T. / Kitamura, N. / Urano, N. / Maruoka, S. / Ohtsuka, J. / Nagata, K. ...Qin, H.-M. / Yamamura, A. / Miyakawa, T. / Kataoka, M. / Nagai, T. / Kitamura, N. / Urano, N. / Maruoka, S. / Ohtsuka, J. / Nagata, K. / Shimizu, S. / Tanokura, M.
External linksAppl. Microbiol. Biotechnol. / PubMed:23828603
MethodsX-ray diffraction
Resolution1.7 - 1.8 Å
Structure data

PDB-3vxg:
Crystal structure of conjugated polyketone reductase C2 from Candida Parapsilosis
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-4h8n:
Crystal structure of conjugated polyketone reductase C2 from candida parapsilosis complexed with NADPH
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

Source
  • candida parapsilosis (yeast)
KeywordsOXIDOREDUCTASE / TIM BARREL / D-PANTOYL LACTONE

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