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TitleDiscovery of triazines as potent, selective and orally active PDE4 inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 23, Page 4308-4314, Year 2013
Publish dateMay 13, 2013 (structure data deposition date)
AuthorsGewald, R. / Grunwald, C. / Egerland, U.
External linksBioorg. Med. Chem. Lett. / PubMed:23806553
MethodsX-ray diffraction
Resolution1.5 Å
Structure data

PDB-4kp6:
Crystal structure of human phosphodiesterase 4B (PDE4B) in complex with a [1,3,5]triazine derivative
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

Chemicals

ChemComp-1S1:
2-ethyl-2-{[4-(methylamino)-6-(1H-1,2,4-triazol-1-yl)-1,3,5-triazin-2-yl]amino}butanenitrile

ChemComp-MG:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / PDE4 inhibitor / phosphodiesterase / triazine / neutrophilia / COPD / HYDROLASE-HYDROLASE INHIBITOR complex

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