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-Structure paper
Title | The Identification of Novel P38-Alpha Isoform Selective Kinase Inhibitors Having an Unprecedented P38-Alpha Binding Mode |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 23, Page 4120-4126, Year 2013 |
Publish date | May 2, 2013 (structure data deposition date) |
Authors | Wrobleski, S.T. / Lin, S. / Murali Dhar, T.G. / Dyckman, A.J. / Li, T. / Pitt, S. / Zhang, R. / Fan, Y. / Doweyko, A.M. / Tokarski, J.S. ...Wrobleski, S.T. / Lin, S. / Murali Dhar, T.G. / Dyckman, A.J. / Li, T. / Pitt, S. / Zhang, R. / Fan, Y. / Doweyko, A.M. / Tokarski, J.S. / Kish, K.F. / Kiefer, S.E. / Sack, J.S. / Newitt, J.A. / Witmer, M.R. / McKinnon, M. / Barrish, J.C. / Dodd, J.H. / Schieven, G.L. / Leftheris, K. |
External links | Bioorg. Med. Chem. Lett. / PubMed:23746475 |
Methods | X-ray diffraction |
Resolution | 1.97 - 2.5 Å |
Structure data | PDB-4kin: PDB-4kip: PDB-4kiq: |
Chemicals | ChemComp-1M8: ChemComp-HOH: ChemComp-1R9: ChemComp-1RA: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / SERINE/THREONINE-PROTEIN KINASE / KINASE / TRANSFERASE / P38 MAP KINASE / TRANSFERASE-TRANSFERASE INHIBITOR complex |