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TitleMutant IDH1 Enhances the Production of 2-Hydroxyglutarate Due to Its Kinetic Mechanism.
Journal, issue, pagesBiochemistry, Vol. 52, Page 4563-4577, Year 2013
Publish dateMay 30, 2013 (structure data deposition date)
AuthorsRendina, A.R. / Pietrak, B. / Smallwood, A. / Zhao, H. / Qi, H. / Quinn, C. / Adams, N.D. / Concha, N. / Duraiswami, C. / Thrall, S.H. ...Rendina, A.R. / Pietrak, B. / Smallwood, A. / Zhao, H. / Qi, H. / Quinn, C. / Adams, N.D. / Concha, N. / Duraiswami, C. / Thrall, S.H. / Sweitzer, S. / Schwartz, B.
External linksBiochemistry / PubMed:23731180
MethodsX-ray diffraction
Resolution2.1 - 2.87 Å
Structure data

PDB-4kzo:
Crystal Structure Analysis of human IDH1 mutants in complex with NADP+ and Ca2+/alpha-Ketoglutarate
Method: X-RAY DIFFRACTION / Resolution: 2.204 Å

PDB-4l03:
Crystal Structure Analysis of human IDH1 mutants in complex with NADP+ and Ca2+/alpha-Ketoglutarate
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-4l04:
Crystal Structure Analysis of human IDH1 mutants in complex with NADP+ and Ca2+/alpha-Ketoglutarate
Method: X-RAY DIFFRACTION / Resolution: 2.87 Å

PDB-4l06:
Crystal Structure Analysis of human IDH1 mutants in complex with NADP+ and Ca2+/alpha-Ketoglutarate
Method: X-RAY DIFFRACTION / Resolution: 2.282 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-AKG:
2-OXOGLUTARIC ACID

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / cytosolic

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