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TitleEngineered SIRP alpha variants as immunotherapeutic adjuvants to anticancer antibodies.
Journal, issue, pagesScience, Vol. 341, Page 88-91, Year 2013
Publish dateMay 4, 2013 (structure data deposition date)
AuthorsWeiskopf, K. / Ring, A.M. / Ho, C.C. / Volkmer, J.P. / Levin, A.M. / Volkmer, A.K. / Ozkan, E. / Fernhoff, N.B. / van de Rijn, M. / Weissman, I.L. / Garcia, K.C.
External linksScience / PubMed:23722425
MethodsX-ray diffraction
Resolution1.93 Å
Structure data

PDB-4kjy:
Complex of high-affinity SIRP alpha variant FD6 with CD47
Method: X-RAY DIFFRACTION / Resolution: 1.93 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Immunoglobulin fold / Immune regulation / N-linked glycosylation / Plasma membrane

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