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Author
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IF

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Structure paper

TitleStructural mechanism of cytosolic DNA sensing by cGAS
Journal, issue, pagesNature, Vol. 498, Page 332-337, Year 2013
Publish dateMar 13, 2013 (structure data deposition date)
AuthorsCivril, F. / Deimling, T. / Mann, C.C.O. / Ablasser, A. / Moldt, M. / Witte, G. / Hornung, V. / Hopfner, K.P.
External linksNature / PubMed:23722159
MethodsX-ray diffraction
Resolution2.004 - 3.0754 Å
Structure data

PDB-4jlx:
Structure of porcine cyclic GMP-AMP synthase (cGAS)
Method: X-RAY DIFFRACTION / Resolution: 2.004 Å

PDB-4jlz:
Structure of porcine cGAS in complex with bound UTP
Method: X-RAY DIFFRACTION / Resolution: 2.27 Å

PDB-4kb6:
Structure of porcine cyclic GMP AMP synthase (CGAS) in complex with DNA, ATP and GTP
Method: X-RAY DIFFRACTION / Resolution: 3.0754 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MLI:
MALONATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

ChemComp-UTP:
URIDINE 5'-TRIPHOSPHATE / UTP*YM

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

Source
  • sus scrofa (pig)
  • synthetic dna (others)
KeywordsDNA BINDING PROTEIN / TRANSFERASE/DNA / OAS-like fold / Receptor / Immunity / cGAS / double stranded DNA / GTP / cytosol / TRANSFERASE-DNA complex

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