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TitleA Potent and Selective Small-Molecule Inhibitor for the Lymphoid-Specific Tyrosine Phosphatase (LYP), a Target Associated with Autoimmune Diseases.
Journal, issue, pagesJ. Med. Chem., Vol. 56, Page 4990-5008, Year 2013
Publish dateFeb 7, 2013 (structure data deposition date)
AuthorsHe, Y. / Liu, S. / Menon, A. / Stanford, S. / Oppong, E. / Gunawan, A.M. / Wu, L. / Wu, D.J. / Barrios, A.M. / Bottini, N. ...He, Y. / Liu, S. / Menon, A. / Stanford, S. / Oppong, E. / Gunawan, A.M. / Wu, L. / Wu, D.J. / Barrios, A.M. / Bottini, N. / Cato, A.C. / Zhang, Z.Y.
External linksJ. Med. Chem. / PubMed:23713581
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-4j51:
Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular inhibitor L75N04
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-N75:
3-[(3-chlorophenyl)ethynyl]-2-{4-[2-(cyclopropylamino)-2-oxoethoxy]phenyl}-6-hydroxy-1-benzofuran-5-carboxylic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / HYDROLASE / TYROSINE PHOSPHATASE / inhibitor design / HYDROLASE-HYDROLASE INHIBITOR complex

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