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TitleMolecular Mechanism of Peroxisome Proliferator-Activated Receptor Alpha Activation by Wy14643: A New Mode of Ligand Recognition and Receptor Stabilization
Journal, issue, pagesJ. Mol. Biol., Vol. 425, Page 2878-, Year 2013
Publish dateOct 2, 2012 (structure data deposition date)
AuthorsBernardes, A. / T Souza, P.C. / Muniz, J.R.C. / Ricci, C.G. / Ayers, S.D. / Parekh, N.M. / Godoy, A.S. / Trivella, D.B.B. / Reinach, P. / Webb, P. ...Bernardes, A. / T Souza, P.C. / Muniz, J.R.C. / Ricci, C.G. / Ayers, S.D. / Parekh, N.M. / Godoy, A.S. / Trivella, D.B.B. / Reinach, P. / Webb, P. / Skaf, M.S. / Polikarpov, I.
External linksJ. Mol. Biol. / PubMed:23707408
MethodsX-ray diffraction
Resolution2.497 Å
Structure data

PDB-4bcr:
Structure of PPARalpha in complex with WY14643
Method: X-RAY DIFFRACTION / Resolution: 2.497 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-WY1:
2-({4-CHLORO-6-[(2,3-DIMETHYLPHENYL)AMINO]PYRIMIDIN-2-YL}SULFANYL)ACETIC ACID / agonist*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / NUCLEAR RECEPTOR / PPAR / FIBRATE

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