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Structure paper

TitleTetrahydrobiopterin biosynthesis as an off-target of sulfa drugs.
Journal, issue, pagesScience, Vol. 340, Page 987-991, Year 2013
Publish dateNov 8, 2012 (structure data deposition date)
AuthorsHaruki, H. / Pedersen, M.G. / Gorska, K.I. / Pojer, F. / Johnsson, K.
External linksScience / PubMed:23704574
MethodsX-ray diffraction
Resolution2.4 - 2.44 Å
Structure data

PDB-4hwk:
Crystal structure of human sepiapterin reductase in complex with sulfapyridine
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-4j7u:
Crystal structure of human sepiapterin reductase in complex with sulfathiazole
Method: X-RAY DIFFRACTION / Resolution: 2.44 Å

Chemicals

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-SFY:
4-amino-N-(pyridin-2-yl)benzenesulfonamide / medication, antibiotic*YM

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-HOH:
WATER

ChemComp-YTZ:
4-amino-N-(1,3-thiazol-2-yl)benzenesulfonamide / Antimicrobial*YM

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE/ANTIBIOTIC / Reductase / OXIDOREDUCTASE-ANTIBIOTIC complex

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