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TitleInhibitors that stabilize a closed RAF kinase domain conformation induce dimerization.
Journal, issue, pagesNat. Chem. Biol., Vol. 9, Page 428-436, Year 2013
Publish dateMar 25, 2013 (structure data deposition date)
AuthorsLavoie, H. / Thevakumaran, N. / Gavory, G. / Li, J.J. / Padeganeh, A. / Guiral, S. / Duchaine, J. / Mao, D.Y. / Bouvier, M. / Sicheri, F. / Therrien, M.
External linksNat. Chem. Biol. / PubMed:23685672
MethodsX-ray diffraction
Resolution3.09 Å
Structure data

PDB-4jvg:
B-Raf Kinase in Complex with Birb796
Method: X-RAY DIFFRACTION / Resolution: 3.09 Å

Chemicals

ChemComp-B96:
1-(5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YL)-3-[4-(2-MORPHOLIN-4-YL-ETHOXY)-NAPHTHALEN-1-YL]-UREA

Source
  • homo sapiens (human)
KeywordsTransferase/transferase inhibitor / kinase / phosphotransferase / Transferase-transferase inhibitor complex

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