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Structure paper

TitleUnexpected Non-Hoogsteen-Based Mutagenicity Mechanism of Fapy-DNA Lesions.
Journal, issue, pagesNat. Chem. Biol., Vol. 9, Page 455-, Year 2013
Publish dateSep 5, 2012 (structure data deposition date)
AuthorsGehrke, T.H. / Lischke, U. / Gasteiger, K.L. / Schneider, S. / Arnold, S. / Muller, H.C. / Stephenson, D.S. / Zipse, H. / Carell, T.
External linksNat. Chem. Biol. / PubMed:23685671
MethodsX-ray diffraction
Resolution1.73 - 2.65 Å
Structure data

PDB-4b9l:
Structure of the high fidelity DNA polymerase I with the oxidative formamidopyrimidine-dA DNA lesion in the pre-insertion site.
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

PDB-4b9m:
Structure of the high fidelity DNA polymerase I with an oxidative formamidopyrimidine-dA DNA lesion -thymine basepair in the post- insertion site.
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

PDB-4b9n:
Structure of the high fidelity DNA polymerase I correctly bypassing the oxidative formamidopyrimidine-dA DNA lesion.
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-4b9s:
Structure of the high fidelity DNA polymerase I with an oxidative formamidopyrimidine-dG DNA lesion outside of the pre-insertion site.
Method: X-RAY DIFFRACTION / Resolution: 1.73 Å

PDB-4b9t:
Structure of the high fidelity DNA polymerase I with an oxidative formamidopyrimidine-dG DNA lesion -dC basepair in the post-insertion site.
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

PDB-4b9u:
Structure of the high fidelity DNA polymerase I with an oxidative formamidopyrimidine-dG DNA lesion -dA basepair in the post-insertion site.
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-4b9v:
Structure of the high fidelity DNA polymerase I with extending from an oxidative formamidopyrimidine-dG DNA lesion -dA basepair.
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • geobacillus stearothermophilus (bacteria)
KeywordsTRANSFERASE/DNA / TRANSFERASE-DNA COMPLEX / OXIDATIVE DNA LESION / DNA DAMAGE / TRANS LESION SYNTHESIS / REPLICATION / TRANSLESION DNA SYNTHESIS / DNA POLYMERASE

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