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Title | Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. |
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Journal, issue, pages | ACS Chem. Biol., Vol. 8, Page 1488-1496, Year 2013 |
Publish date | Jun 3, 2013 (structure data deposition date) |
Authors | Chowdhury, R. / Candela-Lena, J.I. / Chan, M.C. / Greenald, D.J. / Yeoh, K.K. / Tian, Y.M. / McDonough, M.A. / Tumber, A. / Rose, N.R. / Conejo-Garcia, A. ...Chowdhury, R. / Candela-Lena, J.I. / Chan, M.C. / Greenald, D.J. / Yeoh, K.K. / Tian, Y.M. / McDonough, M.A. / Tumber, A. / Rose, N.R. / Conejo-Garcia, A. / Demetriades, M. / Mathavan, S. / Kawamura, A. / Lee, M.K. / van Eeden, F. / Pugh, C.W. / Ratcliffe, P.J. / Schofield, C.J. |
External links | ACS Chem. Biol. / PubMed:23683440 |
Methods | X-ray diffraction |
Resolution | 1.53 - 1.79 Å |
Structure data | PDB-4bqw: PDB-4bqx: PDB-4bqy: |
Chemicals | ChemComp-MN: ChemComp-QNM: ChemComp-HOH: ChemComp-UN9: ChemComp-FE2: ChemComp-FNT: |
Source |
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Keywords | OXIDOREDUCTASE / 2-OXOGLUTARATE / DIOXYGENASE / EGLN / OXYGENASE / DNA-BINDING / TRANSCRIPTION / DSBH / FACIAL TRIAD / ASPARAGINYL/ ASPARTYL HYDROXYLASE / TRANSCRIPTION AND EPIGENETIC REGULATION / SIGNALING / DEVELOPMENT / CELL STRUCTURE / ANKYRIN REPEAT DOMAIN / ARD / BETA-HYDROXYLATION / TRANSCRIPTION ACTIVATOR/INHIBITOR / PHOSPHORYLATION / S-NITROSYLATION / HYPOXIA / METAL-BINDING |