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Structure paper

TitleSelective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
Journal, issue, pagesACS Chem. Biol., Vol. 8, Page 1488-1496, Year 2013
Publish dateJun 3, 2013 (structure data deposition date)
AuthorsChowdhury, R. / Candela-Lena, J.I. / Chan, M.C. / Greenald, D.J. / Yeoh, K.K. / Tian, Y.M. / McDonough, M.A. / Tumber, A. / Rose, N.R. / Conejo-Garcia, A. ...Chowdhury, R. / Candela-Lena, J.I. / Chan, M.C. / Greenald, D.J. / Yeoh, K.K. / Tian, Y.M. / McDonough, M.A. / Tumber, A. / Rose, N.R. / Conejo-Garcia, A. / Demetriades, M. / Mathavan, S. / Kawamura, A. / Lee, M.K. / van Eeden, F. / Pugh, C.W. / Ratcliffe, P.J. / Schofield, C.J.
External linksACS Chem. Biol. / PubMed:23683440
MethodsX-ray diffraction
Resolution1.53 - 1.79 Å
Structure data

PDB-4bqw:
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Mn(II) and 2-(4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid
Method: X-RAY DIFFRACTION / Resolution: 1.79 Å

PDB-4bqx:
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
Method: X-RAY DIFFRACTION / Resolution: 1.79 Å

PDB-4bqy:
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Fe(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]alanine
Method: X-RAY DIFFRACTION / Resolution: 1.53 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-QNM:
2-[(1-methyl-2-oxidanyl-4-oxidanylidene-quinolin-3-yl)carbonylamino]ethanoic acid

ChemComp-HOH:
WATER

ChemComp-UN9:
N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE

ChemComp-FE2:
Unknown entry

ChemComp-FNT:
(2S)-2-{[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]amino}propanoic acid

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / 2-OXOGLUTARATE / DIOXYGENASE / EGLN / OXYGENASE / DNA-BINDING / TRANSCRIPTION / DSBH / FACIAL TRIAD / ASPARAGINYL/ ASPARTYL HYDROXYLASE / TRANSCRIPTION AND EPIGENETIC REGULATION / SIGNALING / DEVELOPMENT / CELL STRUCTURE / ANKYRIN REPEAT DOMAIN / ARD / BETA-HYDROXYLATION / TRANSCRIPTION ACTIVATOR/INHIBITOR / PHOSPHORYLATION / S-NITROSYLATION / HYPOXIA / METAL-BINDING

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