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TitleDelineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization.
Journal, issue, pagesScience, Vol. 340, Page 751-756, Year 2013
Publish dateFeb 11, 2013 (structure data deposition date)
AuthorsGeorgiev, I.S. / Doria-Rose, N.A. / Zhou, T. / Kwon, Y.D. / Staupe, R.P. / Moquin, S. / Chuang, G.Y. / Louder, M.K. / Schmidt, S.D. / Altae-Tran, H.R. ...Georgiev, I.S. / Doria-Rose, N.A. / Zhou, T. / Kwon, Y.D. / Staupe, R.P. / Moquin, S. / Chuang, G.Y. / Louder, M.K. / Schmidt, S.D. / Altae-Tran, H.R. / Bailer, R.T. / McKee, K. / Nason, M. / O'Dell, S. / Ofek, G. / Pancera, M. / Srivatsan, S. / Shapiro, L. / Connors, M. / Migueles, S.A. / Morris, L. / Nishimura, Y. / Martin, M.A. / Mascola, J.R. / Kwong, P.D.
External linksScience / PubMed:23661761
MethodsX-ray diffraction
Resolution1.64 - 2.6 Å
Structure data

PDB-4j6r:
Crystal structure of broadly and potently neutralizing antibody VRC23 in complex with HIV-1 gp120
Method: X-RAY DIFFRACTION / Resolution: 1.64 Å

PDB-4jb9:
Crystal structure of antibody VRC06 in complex with HIV-1 gp120 core
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-CA:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-BU3:
(R,R)-2,3-BUTANEDIOL

ChemComp-HOH:
WATER

Source
  • human immunodeficiency virus 1
  • homo sapiens (human)
Keywordsviral protein/immune system / HIV / GP120 / CD4-binding site / VRC23 / NEUTRALIZATION / VACCINE / Antibody / envelope protein / immune system / viral protein-immune system complex / HIV-1 / VRC06 / glycoprotein

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