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Structure paper

TitlePyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.
Journal, issue, pagesJ. Med. Chem., Vol. 56, Page 3996-4016, Year 2013
Publish dateJan 19, 2013 (structure data deposition date)
AuthorsZhang, F. / Bhat, S. / Gabelli, S.B. / Chen, X. / Miller, M.S. / Nacev, B.A. / Cheng, Y.L. / Meyers, D.J. / Tenney, K. / Shim, J.S. ...Zhang, F. / Bhat, S. / Gabelli, S.B. / Chen, X. / Miller, M.S. / Nacev, B.A. / Cheng, Y.L. / Meyers, D.J. / Tenney, K. / Shim, J.S. / Crews, P. / Amzel, L.M. / Ma, D. / Liu, J.O.
External linksJ. Med. Chem. / PubMed:23634668
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-4iu6:
Human Methionine Aminopeptidase in complex with FZ1: Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-CO:
Unknown entry

ChemComp-K:
Unknown entry

ChemComp-FZ1:
4-[4-(4-methoxyphenyl)piperazin-1-yl]-2-(pyridin-2-yl)quinazoline

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
Keywordshydrolase/hydrolase inhibitor / MetAp1 / Methionine Aminopeptidase 1 / Methionine Aminopeptidase / hydrolase-hydrolase inhibitor complex

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