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TitleEngineering a Monomeric Fc Domain Modality by N-Glycosylation for the Half-life Extension of Biotherapeutics.
Journal, issue, pagesJ. Biol. Chem., Vol. 288, Page 16529-16537, Year 2013
Publish dateJan 31, 2013 (structure data deposition date)
AuthorsIshino, T. / Wang, M. / Mosyak, L. / Tam, A. / Duan, W. / Svenson, K. / Joyce, A. / O'Hara, D.M. / Lin, L. / Somers, W.S. / Kriz, R.
External linksJ. Biol. Chem. / PubMed:23615911
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-4j12:
monomeric Fc
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / immunoglobulin fold

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