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Structure paper

TitleStructures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression.
Journal, issue, pagesJ. Biol. Chem., Vol. 288, Page 16949-16959, Year 2013
Publish dateJul 24, 2012 (structure data deposition date)
AuthorsJiang, X. / Huang, Q. / Wang, W. / Dong, H. / Ly, H. / Liang, Y. / Dong, C.
External linksJ. Biol. Chem. / PubMed:23615902
MethodsX-ray diffraction
Resolution1.68 - 2.46 Å
Structure data

PDB-4g9z:
Lassa nucleoprotein with dsRNA reveals novel mechanism for immune suppression
Method: X-RAY DIFFRACTION / Resolution: 2.03 Å

PDB-4gv3:
Structures of Lassa and Tacaribe viral nucleoproteins with or without 5 triphosphate dsRNA substrate reveal a unique 3 -5 exoribonuclease mechanism to suppress type I interferon production
Method: X-RAY DIFFRACTION / Resolution: 1.68 Å

PDB-4gv6:
Structures of Lassa and Tacaribe viral nucleoproteins with or without 5 triphosphate dsRNA substrate reveal a unique 3 -5 exoribonuclease mechanism to suppress type I interferon production
Method: X-RAY DIFFRACTION / Resolution: 1.98 Å

PDB-4gv9:
Lassa nucleoprotein C-terminal domain in complex with triphosphated dsRNA soaking for 5 min
Method: X-RAY DIFFRACTION / Resolution: 2.46 Å

PDB-4gve:
Tacaribe nucleoprotein structure
Method: X-RAY DIFFRACTION / Resolution: 1.73 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-MN:
Unknown entry

ChemComp-MG:
Unknown entry

Source
  • lassa virus
  • tacaribe virus
KeywordsVIRAL PROTEIN/RNA / Structural Genomics / Scottish Structural Proteomics Facility / SSPF / 3'-5'-ribonuclease / nuclease / VIRAL PROTEIN-RNA complex / RNA BINDING PROTEIN/RNA / DDEDH family / 3'-5'exoribonuclease / RNA BINDING PROTEIN-RNA complex / DEDDH family enzyme / 3'-5' exonuclease / dsRNA / VIRAL PROTEIN

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