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Title | Protein Kinase Inhibitor Design by Targeting the Asp-Phe-Gly (DFG) Motif: The Role of the DFG Motif in the Design of Epidermal Growth Factor Receptor Inhibitors |
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Journal, issue, pages | J. Med. Chem., Vol. 56, Page 3889-3903, Year 2013 |
Publish date | Mar 20, 2013 (structure data deposition date) |
Authors | Peng, Y.H. / Shiao, H.Y. / Tu, C.H. / Liu, P.M. / Hsu, J.T. / Amancha, P.K. / Wu, J.S. / Coumar, M.S. / Chen, C.H. / Wang, S.Y. ...Peng, Y.H. / Shiao, H.Y. / Tu, C.H. / Liu, P.M. / Hsu, J.T. / Amancha, P.K. / Wu, J.S. / Coumar, M.S. / Chen, C.H. / Wang, S.Y. / Lin, W.H. / Sun, H.Y. / Chao, Y.S. / Lyu, P.C. / Hsieh, H.P. / Wu, S.Y. |
External links | J. Med. Chem. / PubMed:23611691 |
Methods | X-ray diffraction |
Resolution | 2.7 - 2.83 Å |
Structure data | PDB-4jq7: PDB-4jq8: PDB-4jr3: PDB-4jrv: |
Chemicals | ChemComp-KJQ: ChemComp-HOH: ChemComp-KJ8: ChemComp-KJR: ChemComp-KJV: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / Transferase / tyrosine kinase domain / ATP-binding domain / autophosphorylation / TRANSFERASE-TRANSFERASE INHIBITOR complex |