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TitleIdentification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 23, Page 3325-3328, Year 2013
Publish dateJan 28, 2013 (structure data deposition date)
AuthorsGoto, T. / Shiina, A. / Yoshino, T. / Mizukami, K. / Hirahara, K. / Suzuki, O. / Sogawa, Y. / Takahashi, T. / Mikkaichi, T. / Nakao, N. ...Goto, T. / Shiina, A. / Yoshino, T. / Mizukami, K. / Hirahara, K. / Suzuki, O. / Sogawa, Y. / Takahashi, T. / Mikkaichi, T. / Nakao, N. / Takahashi, M. / Hasegawa, M. / Sasaki, S.
External linksBioorg. Med. Chem. Lett. / PubMed:23602400
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-3w5e:
Crystal structure of phosphodiesterase 4B in complex with compound 31e
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-NVW:
N-tert-butyl-2-{4-[(5,5-dioxido-2-phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl}acetamide

ChemComp-ZN:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / phosphodiesterase / COPD / inhibitor / HYDROLASE-HYDROLASE INHIBITOR complex

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