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TitlePotency switch between CHK1 and MK2: discovery of imidazo[1,2-a]pyrazine- and imidazo[1,2-c]pyrimidine-based kinase inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 23, Page 2863-2867, Year 2013
Publish dateMar 6, 2013 (structure data deposition date)
AuthorsMeng, Z. / Ciavarri, J.P. / McRiner, A. / Zhao, Y. / Zhao, L. / Reddy, P.A. / Zhang, X. / Fischmann, T.O. / Whitehurst, C. / Arshad Siddiqui, M.
External linksBioorg. Med. Chem. Lett. / PubMed:23587425
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-4jik:
X-RAY Crystal structure of compound 22a (R)-2-(4-chlorophenyl)-8-(piperidin-3-ylamino)imidazo[1,2-c]pyrimidine-5-carboxamide bound to human chk1 kinase domain
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-1KO:
2-(4-chlorophenyl)-8-[(3S)-piperidin-3-ylamino]imidazo[1,2-c]pyrimidine-5-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / KINASE PHOSPHATASE TRANSFERASE / TRANSFERASE-TRANSFERASE INHIBITOR complex

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