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-Structure paper
Title | Kinetic and Structural Analysis for Potent Antifolate Inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and Human Dihydrofolate Reductases and Their Active-Site Variants. |
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Journal, issue, pages | Antimicrob. Agents Chemother., Vol. 57, Page 2669-2677, Year 2013 |
Publish date | Dec 17, 2009 (structure data deposition date) |
![]() | Cody, V. / Pace, J. / Queener, S.F. / Adair, O.O. / Gangjee, A. |
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Methods | X-ray diffraction |
Resolution | 1.35 - 2 Å |
Structure data | ![]() PDB-3l3r: ![]() PDB-3oaf: ![]() PDB-4g8z: ![]() PDB-4g95: |
Chemicals | ![]() ChemComp-OAG: ![]() ChemComp-NDP: ![]() ChemComp-SO4: ![]() ChemComp-HOH: ![]() ChemComp-TOP: |
Source |
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![]() | OXIDOREDUCTASE / dihydrofolate reductase / antifolate / active site mutants / NADP / One-carbon metabolism / OXIDOREDUCTASE/INHIBITOR / hDHFR inhibitor complexes / OXIDOREDUCTASE-INHIBITOR complex / OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / mutant pcDHFR inhibitor complex / TMP/NADPH ligands / K37S and F69N mutations / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex |