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TitleSomatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization.
Journal, issue, pagesCell(Cambridge,Mass. ), Vol. 153, Page 126-138, Year 2013
Publish dateAug 31, 2012 (structure data deposition date)
AuthorsKlein, F. / Diskin, R. / Scheid, J.F. / Gaebler, C. / Mouquet, H. / Georgiev, I.S. / Pancera, M. / Zhou, T. / Incesu, R.B. / Fu, B.Z. ...Klein, F. / Diskin, R. / Scheid, J.F. / Gaebler, C. / Mouquet, H. / Georgiev, I.S. / Pancera, M. / Zhou, T. / Incesu, R.B. / Fu, B.Z. / Gnanapragasam, P.N. / Oliveira, T.Y. / Seaman, M.S. / Kwong, P.D. / Bjorkman, P.J. / Nussenzweig, M.C.
External linksCell(Cambridge,Mass. ) / PubMed:23540694
MethodsX-ray diffraction
Resolution2.65 - 2.904 Å
Structure data

PDB-4gw4:
Crystal structure of 3BNC60 Fab with P61A mutation
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

PDB-4jpv:
Crystal structure of broadly and potently neutralizing antibody 3bnc117 in complex with hiv-1 gp120
Method: X-RAY DIFFRACTION / Resolution: 2.827 Å

PDB-4jpw:
Crystal structure of broadly and potently neutralizing antibody 12a21 in complex with hiv-1 strain 93th057 gp120 mutant
Method: X-RAY DIFFRACTION / Resolution: 2.904 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-EDO:
1,2-ETHANEDIOL

Source
  • homo sapiens (human)
  • human immunodeficiency virus 1
KeywordsIMMUNE SYSTEM / FWR / IgG / Anti HIV / gp120 / HIV / viral protein/immune system / CD4-BINDING SITE / 3BNC117 / NEUTRALIZATION / VACCINE / ANTIBODY / ENVELOPE PROTEIN / VIRAL PROTEIN-IMMUNE SYSTEM COMPLEX / 12A21

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