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-Structure paper
Title | Spirocyclic beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid beta in a higher species. |
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Journal, issue, pages | J. Med. Chem., Vol. 56, Page 3379-3403, Year 2013 |
Publish date | Mar 18, 2013 (structure data deposition date) |
![]() | Hunt, K.W. / Cook, A.W. / Watts, R.J. / Clark, C.T. / Vigers, G. / Smith, D. / Metcalf, A.T. / Gunawardana, I.W. / Burkard, M. / Cox, A.A. ...Hunt, K.W. / Cook, A.W. / Watts, R.J. / Clark, C.T. / Vigers, G. / Smith, D. / Metcalf, A.T. / Gunawardana, I.W. / Burkard, M. / Cox, A.A. / Geck Do, M.K. / Dutcher, D. / Thomas, A.A. / Rana, S. / Kallan, N.C. / DeLisle, R.K. / Rizzi, J.P. / Regal, K. / Sammond, D. / Groneberg, R. / Siu, M. / Purkey, H. / Lyssikatos, J.P. / Marlow, A. / Liu, X. / Tang, T.P. |
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Methods | X-ray diffraction |
Resolution | 1.8 Å |
Structure data | ![]() PDB-4joo: ![]() PDB-4jp9: ![]() PDB-4jpc: ![]() PDB-4jpe: |
Chemicals | ![]() ChemComp-NI: ![]() ChemComp-1M4: ![]() ChemComp-HOH: ![]() ChemComp-1M5: ![]() ChemComp-1M6: ![]() ChemComp-1M7: |
Source |
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![]() | HYDROLASE/HYDROLASE INHIBITOR / Aspartyl protease / HYDROLASE-HYDROLASE INHIBITOR complex |