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Structure paper

TitleChemical engineering and structural and pharmacological characterization of the alpha-scorpion toxin OD1.
Journal, issue, pagesAcs Chem. Biol., Vol. 8, Page 1215-1222, Year 2013
Publish dateOct 9, 2012 (structure data deposition date)
AuthorsDurek, T. / Vetter, I. / Wang, C.I. / Motin, L. / Knapp, O. / Adams, D.J. / Lewis, R.J. / Alewood, P.F.
External linksAcs Chem. Biol. / PubMed:23527544
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-4hhf:
Crystal Structure of chemically synthesized scorpion alpha-toxin OD1
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-HOH:
WATER

Source
  • odontobuthus doriae (scorpion)
KeywordsTOXIN / scorpion long-chain alpha-toxin / gating modulator / voltage-gated sodium channels 1.4 / 1.6 / 1.7 / inhibition of fast channel inactivation / C-terminally amidated / venom gland

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