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-Structure paper
Title | 2-Hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs), novel inhibitors of HIV integrase with a high barrier to resistance. |
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Journal, issue, pages | Acs Chem. Biol., Vol. 8, Page 1187-1194, Year 2013 |
Publish date | Dec 26, 2012 (structure data deposition date) |
![]() | Desimmie, B.A. / Demeulemeester, J. / Suchaud, V. / Taltynov, O. / Billamboz, M. / Lion, C. / Bailly, F. / Strelkov, S.V. / Debyser, Z. / Cotelle, P. / Christ, F. |
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Methods | X-ray diffraction |
Resolution | 3.4 Å |
Structure data | ![]() PDB-4ikf: |
Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-SO4: ![]() ChemComp-NH4: ![]() ChemComp-MG: ![]() ChemComp-GOL: ![]() ChemComp-HEZ: ![]() ChemComp-M76: |
Source |
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![]() | VIRAL PROTEIN/DNA/INHIBITOR / Integrase zinc binding / core and DNA-binding domains / DNA integration / Inhibitor / Nucleus / VIRAL PROTEIN-DNA-INHIBITOR complex / endonuclease / nucleotidyltransferase / recombination / HHCC motif / DDE motif |