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TitleStructural basis for treating tumor necrosis factor alpha (TNFalpha)-associated diseases with the therapeutic antibody infliximab
Journal, issue, pagesJ. Biol. Chem., Vol. 288, Page 13799-13807, Year 2013
Publish dateJul 15, 2012 (structure data deposition date)
AuthorsLiang, S.Y. / Dai, J.X. / Hou, S. / Su, L. / Zhang, D. / Guo, H. / Hu, S. / Wang, H. / Rao, Z. / Guo, Y.J. / Lou, Z.Y.
External linksJ. Biol. Chem. / PubMed:23504311
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-4g3y:
Crystal structure of TNF-alpha in complex with Infliximab Fab fragment
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / TNF / Infliximab

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