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-Structure paper
Title | Synthesis and structure-activity relationships for 1-(4-(piperidin-1-ylsulfonyl)phenyl)pyrrolidin-2-ones as novel non-carboxylate inhibitors of the aldo-keto reductase enzyme AKR1C3. |
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Journal, issue, pages | Eur. J. Med. Chem., Vol. 62C, Page 738-744, Year 2013 |
Publish date | Sep 20, 2012 (structure data deposition date) |
![]() | Heinrich, D.M. / Flanagan, J.U. / Jamieson, S.M. / Silva, S. / Rigoreau, L.J. / Trivier, E. / Raynham, T. / Turnbull, A.P. / Denny, W.A. |
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Methods | X-ray diffraction |
Resolution | 1.97 Å |
Structure data | ![]() PDB-4h7c: |
Chemicals | ![]() ChemComp-NAP: ![]() ChemComp-10H: ![]() ChemComp-HOH: |
Source |
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![]() | oxidoreductase/oxidoreductase inhibitor / TIM-barrel / aldo-keto reductase / oxidoreductase-oxidoreductase inhibitor complex |