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Structure paper

TitleStructural integrity of the B24 site in human insulin is important for hormone functionality.
Journal, issue, pagesJ. Biol. Chem., Vol. 288, Page 10230-10240, Year 2013
Publish dateDec 28, 2012 (structure data deposition date)
AuthorsZakova, L. / Kletvikova, E. / Veverka, V. / Lepsik, M. / Watson, C.J. / Turkenburg, J.P. / Jiracek, J. / Brzozowski, A.M.
External linksJ. Biol. Chem. / PubMed:23447530
MethodsNMR (solution) / X-ray diffraction
Resolution1.7 Å
Structure data

PDB-2m2m:
Structure of [L-HisB24] insulin analogue at pH 1.9
Method: SOLUTION NMR

PDB-2m2n:
Structure of [L-HisB24] insulin analogue at pH 8.0
Method: SOLUTION NMR

PDB-2m2o:
Structure of [D-HisB24] insulin analogue at pH 1.9
Method: SOLUTION NMR

PDB-2m2p:
Structure of [D-HisB24] insulin analogue at pH 8.0
Method: SOLUTION NMR

PDB-3zi3:
Crystal structure of the B24His-insulin - human analogue
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHORMONE / insulin

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