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TitleSomatic hypermutation maintains antibody thermodynamic stability during affinity maturation.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 110, Page 4261-4266, Year 2013
Publish dateFeb 2, 2013 (structure data deposition date)
AuthorsWang, F. / Sen, S. / Zhang, Y. / Ahmad, I. / Zhu, X. / Wilson, I.A. / Smider, V.V. / Magliery, T.J. / Schultz, P.G.
External linksProc. Natl. Acad. Sci. USA / PubMed:23440204
MethodsX-ray diffraction
Resolution2.58 Å
Structure data

PDB-4j1u:
Crystal structure of antibody 93F3 unstable variant
Method: X-RAY DIFFRACTION / Resolution: 2.58 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / antibody maturation / antibody stability / clonal selection

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