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TitleAllosteric inhibition of hypoxia inducible factor-2 with small molecules.
Journal, issue, pagesNat. Chem. Biol., Vol. 9, Page 271-276, Year 2013
Publish dateAug 7, 2012 (structure data deposition date)
AuthorsScheuermann, T.H. / Li, Q. / Ma, H.W. / Key, J. / Zhang, L. / Chen, R. / Garcia, J.A. / Naidoo, J. / Longgood, J. / Frantz, D.E. ...Scheuermann, T.H. / Li, Q. / Ma, H.W. / Key, J. / Zhang, L. / Chen, R. / Garcia, J.A. / Naidoo, J. / Longgood, J. / Frantz, D.E. / Tambar, U.K. / Gardner, K.H. / Bruick, R.K.
External linksNat. Chem. Biol. / PubMed:23434853
MethodsX-ray diffraction
Resolution1.5 Å
Structure data

PDB-4ghi:
Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in complex with a benzoxadiazole antagonist
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

Chemicals

ChemComp-0X3:
N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / PAS Fold / protein : protein interactions

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