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-Structure paper
Title | Structure-based discovery of cellular-active allosteric inhibitors of FAK. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 23, Page 1779-1785, Year 2013 |
Publish date | Nov 27, 2012 (structure data deposition date) |
![]() | Tomita, N. / Hayashi, Y. / Suzuki, S. / Oomori, Y. / Aramaki, Y. / Matsushita, Y. / Iwatani, M. / Iwata, H. / Okabe, A. / Awazu, Y. ...Tomita, N. / Hayashi, Y. / Suzuki, S. / Oomori, Y. / Aramaki, Y. / Matsushita, Y. / Iwatani, M. / Iwata, H. / Okabe, A. / Awazu, Y. / Isono, O. / Skene, R.J. / Hosfield, D.J. / Miki, H. / Kawamoto, T. / Hori, A. / Baba, A. |
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Methods | X-ray diffraction |
Resolution | 1.55 - 1.75 Å |
Structure data | ![]() PDB-4i4e: ![]() PDB-4i4f: |
Chemicals | ![]() ChemComp-1BQ: ![]() ChemComp-HOH: ![]() ChemComp-IPA: ![]() ChemComp-1BR: |
Source |
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![]() | transferase/transferase inhibitor / Phosphorylated on tyrosines / transferase / Cytoplasmic; localized to focal adhesions / transferase-transferase inhibitor complex / localized to focal adhesions |