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-Structure paper
Title | MDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer Models. |
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Journal, issue, pages | Cancer Res., Vol. 73, Page 2587-2597, Year 2013 |
Publish date | Jan 9, 2013 (structure data deposition date) |
![]() | Tovar, C. / Graves, B. / Packman, K. / Filipovic, Z. / Xia, B.H. / Tardell, C. / Garrido, R. / Lee, E. / Kolinsky, K. / To, K.H. ...Tovar, C. / Graves, B. / Packman, K. / Filipovic, Z. / Xia, B.H. / Tardell, C. / Garrido, R. / Lee, E. / Kolinsky, K. / To, K.H. / Linn, M. / Podlaski, F. / Wovkulich, P. / Vu, B. / Vassilev, L.T. |
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Methods | X-ray diffraction |
Resolution | 1.7 Å |
Structure data | ![]() PDB-4ipf: |
Chemicals | ![]() ChemComp-1F0: ![]() ChemComp-SO4: ![]() ChemComp-HOH: |
Source |
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![]() | LIGASE/ANTAGONIST / MDM2 / P53 / PROTEIN-PROTEIN INTERACTION / IMIDAZOLINE / E3 UBIQUITIN LIGASE / NUCLEUS / LIGASE-ANTAGONIST complex |